Our research strategy carried out in various species (rat, mice, lizards, birds, chameleons, humans etc ) is to disentangle brain networks and biological mechanisms generating sleep and its natural alternation with wakefulness, to unravel either physiological, functional and cognitive functions of sleep and to understand the dysfunctional mechanisms underlying different pathologies affecting sleep with well-documented negative impacts on both health and quality of life of human beings. Our projects and experimental approaches are multidisciplinary, translational and by definition integrative.